Document Detail

Alpha-fetoprotein changes in the course of chronic hepatitis: relation to bridging hepatic necrosis and hepatocellular carcinoma.
MedLine Citation:
PMID:  2427909     Owner:  NLM     Status:  MEDLINE    
To examine the frequency and significance of alpha-fetoprotein (AFP) elevation, radioimmunoassay for AFP was performed every 3-6 months in a prospective follow-up study on 432 hepatitis B surface antigen (HBsAg)-positive and 105 HBsAg-negative patients with clinicopathologically proven chronic hepatitis. In a period of 6-85 months (mean 26.9 +/- 16.8), AFP elevation (greater than 20 ng/ml) was recorded in 45.6% of the HBsAg-positive patients. In addition, 19.4% of the HBsAg-positive patients had AFP levels greater than 100 ng/ml, with a highest level of 2520 ng/ml in the absence of hepatocellular carcinoma (HCC). All these figures were much greater than those for HBsAg-negative patients (P less than 0.001). Most episodes of AFP elevation were transient, with parallel moderate SGPT elevation (greater than 200 IU/L). The AFP levels in such episodes correlated closely with the presence of bridging hepatic necrosis, only weakly with peak SGPT levels, but not with age, sex or hepatitis B e antigen/antibody status. None of the transient episodes was followed by subsequent development of HCC. On the other hand, AFP elevation (greater than 100 ng/ml) without parallel SGPT elevation could predict the presence of HCC with very high specificity (98.7%). However, the sensitivity was not high enough (66.7%) for one to rely solely on AFP for the detection of HCC at its earlier stage.
Y F Liaw; D I Tai; T J Chen; C M Chu; M J Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Liver     Volume:  6     ISSN:  0106-9543     ISO Abbreviation:  Liver     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-10-22     Completed Date:  1986-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200939     Medline TA:  Liver     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / metabolism
Carcinoma, Hepatocellular / blood*,  complications,  diagnosis
Follow-Up Studies
Hepatitis B / blood*,  immunology,  pathology
Hepatitis B Surface Antigens / analysis,  immunology
Hepatitis, Chronic / blood*,  etiology,  pathology
Liver Diseases / blood*
Liver Neoplasms / blood*,  complications,  diagnosis
Middle Aged
Necrosis / blood
Prospective Studies
alpha-Fetoproteins / analysis*
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/alpha-Fetoproteins; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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