| Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones. | |
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MedLine Citation:
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PMID: 16182258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper demonstrates the capacity of the neuronal nicotinic acetylcholine receptor (nAChR) antagonist alpha-conotoxin Vc1.1 to inhibit pain responses in vivo. Vc1.1 suppressed pain behaviors when tested in two models of peripheral neuropathy of the rat sciatic nerve, the chronic constriction injury (CCI) and partial nerve ligation (PNL) models. Mechanical hyperalgesia was assessed using an Ugo Basile Analgesymeter. Vc1.1 was administered by intramuscular bolus injection near the site of injury at doses of 0.036 microg, 0.36 microg and 3.6 microg in CCI rats and at a dose of 0.36 microg in PNL rats. Vc1.1 was also administered contralaterally in CCI rats at doses of 0.36 microg and 3.6 microg. Treatment started after the development of hyperalgesia and continued for 7 days. Vc1.1 significantly attenuated mechanical hyperalgesia in both CCI and PNL rats for up to a week following cessation of treatment. Vc1.1 also accelerated functional recovery of injured neurones. A blister was raised over the footpad innervated by the peripheral terminals of the injured nerve. The ability of these terminals to mount an inflammatory vascular response upon perfusion of the blister base with substance P provided a measure of functional recovery. This study shows that alpha-conotoxin Vc1.1, a neuronal nAChR antagonist, suppressed mechanical pain responses associated with peripheral neuropathy in rats in vivo and accelerated functional recovery of the injured neurones. A role for neuronal nAChRs in the analgesic activity of Vc1.1 is proposed. |
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Authors:
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Narmatha Satkunanathan; Bruce Livett; Ken Gayler; David Sandall; John Down; Zeinab Khalil |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-09-22 |
Journal Detail:
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Title: Brain research Volume: 1059 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-21 Completed Date: 2006-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 149-58 Citation Subset: IM |
Affiliation:
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National Ageing Research Institute, University of Melbourne, Parkville Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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administration & dosage Animals Conotoxins / administration & dosage* Disease Models, Animal Dose-Response Relationship, Drug Male Nicotinic Antagonists / administration & dosage* Pain / drug therapy*, etiology Rats Rats, Sprague-Dawley Receptors, Nicotinic / drug effects*, physiology Recovery of Function / drug effects Sciatic Neuropathy / complications, drug therapy*, physiopathology Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Conotoxins; 0/Nicotinic Antagonists; 0/Receptors, Nicotinic; 0/alpha-conotoxin Vc1.1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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