| Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech. | |
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MedLine Citation:
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PMID: 20833225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medicinal leeches (Hirudo spp.) swim using a metachronal, front-to-back undulation. The behavior is generated by central pattern generators (CPGs) distributed along the animal's midbody ganglia and is coordinated by both central and peripheral mechanisms. Here we report that a component of the venom of Conus imperialis, α-conotoxin ImI, known to block nicotinic acetyl-choline receptors in other species, disrupts swimming. Leeches injected with the toxin swam in circles with exaggerated dorsoventral bends and reduced forward velocity. Fictive swimming in isolated nerve cords was even more strongly disrupted, indicating that the toxin targets the CPGs and central coordination, while peripheral coordination partially rescues the behavior in intact animals. |
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Authors:
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Daniel A Wagenaar; Ruben Gonzalez; David C Ries; William B Kristan; Kathleen A French |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Neuroscience letters Volume: 485 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-28 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 151-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Broad Fellows Program and Division of Biology, California Institute of Technology, 1200 E California Blvd 216-76, Pasadena, CA 91125, USA. daw@caltech.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Behavior, Animal / drug effects Biomechanics Central Nervous System / drug effects Conotoxins / pharmacology* Electrophysiological Phenomena Ganglia, Invertebrate / physiology Leeches / physiology* Motor Neurons / drug effects Nicotinic Antagonists / pharmacology* Peripheral Nervous System / drug effects Psychomotor Performance / physiology Receptors, Nicotinic / drug effects* Swimming / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH43396/MH/NIMH NIH HHS; NS35336/NS/NINDS NIH HHS; R01 MH043396-10/MH/NIMH NIH HHS; R01 MH043396-21/MH/NIMH NIH HHS; R01 NS035336-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Conotoxins; 0/Nicotinic Antagonists; 0/Receptors, Nicotinic; 156467-85-5/alpha-conotoxin ImI |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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