Document Detail

Alpha-blockers and urethral pressure in neurological patients.
MedLine Citation:
PMID:  30197     Owner:  NLM     Status:  MEDLINE    
In 11 patients with upper motor neuron bladder paresis due to spinal trauma, 2 patients with lower motor neuron bladder paresis, and 4 patients with multiple sclerosis, alpha-adrenergic blockade with 10 mg Regitine intravenously decreased the maximum urethral closure pressure to an average of 42%. The decrease was most pronounced in a patient with lower motor neuron bladder paresis and a flaccid pelvic floor. Treatment with phenoxybenzamine was found valuable in patients with multiple sclerosis and poor bladder emptying as well as in patients with lower motor neuron bladder paresis. In patients with detrusorsphincter dyssynergia this treatment was of no value.
J Nordling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  33     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  304-9     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Multiple Sclerosis / physiopathology
Paralysis / physiopathology
Phenoxybenzamine / pharmacology
Phentolamine / pharmacology*
Urethra / drug effects*
Urinary Bladder Diseases / physiopathology
Urinary Bladder, Neurogenic / physiopathology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 50-60-2/Phentolamine; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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