| Alpha-beta chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix. | |
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MedLine Citation:
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PMID: 15501034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Novel alpha-beta chimeric oligodeoxynucleotides bearing an intercalator-conjugated nucleobase located at the internal 4-nt linker region were synthesized, and their triplex-stabilizing property was examined. The triple helical DNA formed between the modified chimera DNA and double-stranded DNA exhibited remarkable thermal stability; however, the position of the intercalator-conjugated nucleobase had little influence on the stability. Among the examined, modified chimera DNA bearing the two intercalator-conjugated nucleobases at adjacent positions exhibited the highest stability. |
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Authors:
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A T M Zafrul Azam; Minoru Hasegawa; Tomohisa Moriguchi; Kazuo Shinozuka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 14 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-10-25 Completed Date: 2005-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 5747-50 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chimera
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genetics DNA / chemistry, genetics Intercalating Agents / chemical synthesis* Oligodeoxyribonucleotides / chemical synthesis*, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Intercalating Agents; 0/Oligodeoxyribonucleotides; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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