| Alpha-adrenoreceptor-related dissociation constants and intrinsic efficacies of stereoisomers of epinephrine. | |
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MedLine Citation:
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PMID: 6271313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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THe alpha-adrenoreceptor-related dissociation constant and intrinsic efficacy of the stereoisomers of epinephrine were determined on the rabbit aortic strip. (-)-Epinephrine showed higher affinity than (+)-epinephrine or the desoxy analogue epinine. Efficacy of (+)-epinephrine relative to (-)-epinephrine was low (relative efficacy, er = 0.44). Epinephrine had about the same affinity and efficacy as (+)-epinephrine. When the alpha-adrenoreceptors were protected against dibenamine by an equimolar concentration of the isomers, (-)-epinephrine was found to be more effective than (+)-epinephrine or epinine. These results suggest that the stereoisomers of catecholamines differ not only in affinity but also in intrinsic efficacy. |
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Authors:
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M Y Kim; K Salman; P N Patil |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood vessels Volume: 18 ISSN: 0303-6847 ISO Abbreviation: Blood Vessels Publication Date: 1981 |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0427130 Medline TA: Blood Vessels Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Epinephrine / analogs & derivatives, metabolism* Female Kinetics Male Mathematics Muscle, Smooth, Vascular / metabolism* Rabbits Receptors, Adrenergic / metabolism* Receptors, Adrenergic, alpha / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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USPHS GRANT NO. 17859/SP/CSAP SAMHSA HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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