| Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation. | |
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MedLine Citation:
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PMID: 6255937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a method which allowed the in-situ measurement of segmental coronary vascular resistances, the reaction of arterial and arteriolar sections of the coronary vascular system to alpha-receptor stimulation was studied i anaesthetized dogs. The left coronary artery was cannulated, and the perfusion pressure was kept constant. Allowance was made for extravascular and metabolic influences of alpha-stimulation on coronary vascular resistances. On an average, submaximal alpha-stimulation with xylometazoline increased the arterial resistance by about 60% and the arteriolar resistance by about 90%. The cannulation of the left coronary artery increased the sympathetic reactivity of the arterioles. Moreover, xylometazoline increased the extravascular component of the coronary vascular resistance by about 4%. Thus it can be assumed that under normal in-vivo conditions alpha-receptor vasoconstriction might be less different in coronary arteries and arterioles. Since the arterial resistance ranges from 20% to 50% of total coronary resistance, a sympathetic vasoconstriction of this vascular section might lead even to a critical limitation of coronary blood flow. On the other hand, a predominant constriction in arterioles leads to an increase in peripheral coronary pressure, i.e. to a "reverse coronary steal phenomenon". |
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Authors:
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G Ertl; M Fuchs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Basic research in cardiology Volume: 75 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1980 Sep-Oct |
Date Detail:
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Created Date: 1981-02-26 Completed Date: 1981-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 600-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / physiology Arterioles / physiology Coronary Circulation / drug effects Coronary Vessels / physiology* Dogs Imidazoles / pharmacology Receptors, Adrenergic / pharmacology* Receptors, Adrenergic, alpha / pharmacology* Vascular Resistance / drug effects Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 526-36-3/xylometazoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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