Document Detail

Alpha adrenergic system in medial preoptic area involved in sleep-wakefulness in rats.
MedLine Citation:
PMID:  3013378     Owner:  NLM     Status:  MEDLINE    
The study is aimed at investigating the possible involvement of adrenergic mechanisms in the medial preoptic area (mPOA) for modulation of sleep-wakefulness in rats. In this study, saline, norepinephrine (NE), phenoxybenzamine (PBZ) and propranolol (PROP) were injected in the mPOA in different groups of male rats during the day and night. NE and PBZ were injected, during the day and the night respectively, in some control areas adjoining the mPOA in two other groups of animals. Arousal was produced by NE, and sleep by PBZ when they were applied in the mPOA. All other procedures, including application of NE and PBZ in the control areas and beta blocker (PROP) in the mPOA, did not produce alterations in sleep-wakefulness. These findings provide support for a physiological role played by the alpha adrenergic system in the mPOA for arousal, and area specificity of action of this system.
V Mohan Kumar; S Datta; G S Chhina; B Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  16     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-08-04     Completed Date:  1986-08-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  463-8     Citation Subset:  IM    
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MeSH Terms
Circadian Rhythm
Norepinephrine / pharmacology
Phenoxybenzamine / pharmacology
Preoptic Area / drug effects,  physiology*
Propranolol / pharmacology
Rats, Inbred Strains
Receptors, Adrenergic, alpha / drug effects,  physiology*
Sleep / drug effects,  physiology*
Sleep Stages / drug effects,  physiology
Wakefulness / drug effects,  physiology*
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 51-41-2/Norepinephrine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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