Document Detail

Alpha-MSH and MIF-2 effects on serotonin levels and accumulation in various rat brain areas.
MedLine Citation:
PMID:  4814     Owner:  NLM     Status:  MEDLINE    
Levels as well as accumulation of serotonin (5-HT) were measured in various brain regions of the rat after administration of alpha-melanocyte-stimulating hormone (MSH) and Pro-Leu-Gly-NH2 (MIF-I). The method used in determining the serotonin measured both 5-OH-tryptamine (5-HT) and 5-methoxytryptamine (5-MT). No statistically significant changes in levels or accumulation of serotonin after pargyline injection were found when unoperated control rats were treated with either MSH or MIF-I. Similar treatment of hypophysectomized rats indicated that both peptides significantly (p less than 0.05) lowered serotonin accumulation only in the area of the frontal cortex; a similar but smaller, not statistically significant, decrease was seen in the hypothalamus and hippocampus of the hypophysectomized rat. Since only hypophysectomized rats were affected, no correlation between the behavioral effects of these peptides (which has been found to occur in both unoperated and hypophysectomized rats) and the biochemical changes could be made.
M A Spirtes; R M Kostrzewa; A J Kastin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  3     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:    1975 Nov-Dec
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1011-5     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Cerebral Cortex / metabolism
Hippocampus / metabolism
Hypothalamus / metabolism
MSH Release-Inhibiting Hormone / pharmacology*
Medulla Oblongata / metabolism
Melanocyte-Stimulating Hormones / pharmacology*
Pargyline / pharmacology
Pituitary Gland / physiology
Pons / metabolism
Serotonin / metabolism*
Time Factors
Reg. No./Substance:
50-67-9/Serotonin; 555-57-7/Pargyline; 9002-79-3/Melanocyte-Stimulating Hormones; 9083-38-9/MSH Release-Inhibiting Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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