Document Detail

Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report.
MedLine Citation:
PMID:  21765837     Owner:  NLM     Status:  In-Data-Review    
Background. Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. A deficiency in this protein leads to increased hemorrhage. It is inherited in an autosomal recessive fashion. Case. 30-year-old Gravida 1, Para 0, presented for prenatal care with her first and subsequently her second pregnancy. Her medical history was significant for a known deficiency in alpha II antiplasmin. Her first and second pregnancies were complicated by nonobstetrical hemorrhage requiring transfusions and severe preeclampsia requiring preterm deliveries. Conclusion. Alpha II antiplasmin deficiency resulted in multiple episodes of nonobstetrical hemorrhages requiring transfusion and ultimately preterm deliveries due to severe preeclampsia. Both infants and mother had a good outcome. The presence of this disorder may require a multidisciplinary team approach involving obstetricians, pediatricians, and hematologists. Precis. Alpha II antiplasmin deficiency is a rare autosomal recessive disorder leading to increased fibrinolysis and hemorrhage. We present a case report of a pregnancy complicated by this disorder.
Brenda Dawley
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Publication Detail:
Type:  Journal Article     Date:  2011-05-15
Journal Detail:
Title:  Obstetrics and gynecology international     Volume:  2011     ISSN:  1687-9597     ISO Abbreviation:  Obstet Gynecol Int     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517078     Medline TA:  Obstet Gynecol Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698648     Citation Subset:  -    
Department of Obstetrics and Gynecology, Joan C. Edwards School of Medicine, 1600 Medical Center Drive, Suite 4500 Huntington, WV 25701, USA.
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