| Alpha-Fetoprotein-producing esophageal adenocarcinoma: report of a case. | |
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MedLine Citation:
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PMID: 11759890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alpha-fetoprotein (AFP)-producing esophageal tumors are extremely rare. We report herein the case of a 51-year-old man found to have an AFP-producing adenocarcinoma arising from esophageal proper mucosa. The patient presented for investigation of dysphagia, and esophagogram and endoscopy revealed a lesion about 2 cm in size with a depressed center surrounded by low nodular protrusions in the lower esophagus. The preoperative serum AFP concentration was elevated to 52.4 ng/ml. A subtotal esophagectomy was performed, and macroscopic examination of the resected specimen revealed a superficial protruding lesion. Histopathological studies showed a poorly differentiated adenocarcinoma with a single lymph node metastasis. The tumor had infiltrated the submucosal layer, but there was no evidence of lymphatic or venous invasion. Immunohistochemical study revealed tumor cells positive for AFP. There were no findings of Barrett's epithelium or any mucosal changes due to reflux esophagitis. An elevated AFP level 2 years after the operation led us to suspect tumor recurrence; however, diagnostic imaging studies showed no evidence of a recurrence or metastases. The serum AFP levels responded well to chemotherapy with transient decreased levels, but continued to rise until finally, 5 years after the operation, adenocarcinoma cells were detected in the pleural effusion. Thus, careful monitoring of the serum AFP levels at regular intervals could be a useful marker to indicate recurrence of esophageal carcinoma. |
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Authors:
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N Kobayashi; M Ohbu; S Kuroyama; S Kikuchi; H Shimao; H Mitomi; A Kakita |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Surgery today Volume: 31 ISSN: 0941-1291 ISO Abbreviation: Surg. Today Publication Date: 2001 |
Date Detail:
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Created Date: 2001-12-10 Completed Date: 2002-02-28 Revised Date: 2006-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9204360 Medline TA: Surg Today Country: Japan |
Other Details:
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Languages: eng Pagination: 915-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism*,
surgery Esophageal Neoplasms / metabolism*, surgery Humans Male Middle Aged Neoplasm Proteins / biosynthesis* alpha-Fetoproteins / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Neoplasm Proteins; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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