Document Detail

Alpha-Fetoprotein-producing esophageal adenocarcinoma: report of a case.
MedLine Citation:
PMID:  11759890     Owner:  NLM     Status:  MEDLINE    
Alpha-fetoprotein (AFP)-producing esophageal tumors are extremely rare. We report herein the case of a 51-year-old man found to have an AFP-producing adenocarcinoma arising from esophageal proper mucosa. The patient presented for investigation of dysphagia, and esophagogram and endoscopy revealed a lesion about 2 cm in size with a depressed center surrounded by low nodular protrusions in the lower esophagus. The preoperative serum AFP concentration was elevated to 52.4 ng/ml. A subtotal esophagectomy was performed, and macroscopic examination of the resected specimen revealed a superficial protruding lesion. Histopathological studies showed a poorly differentiated adenocarcinoma with a single lymph node metastasis. The tumor had infiltrated the submucosal layer, but there was no evidence of lymphatic or venous invasion. Immunohistochemical study revealed tumor cells positive for AFP. There were no findings of Barrett's epithelium or any mucosal changes due to reflux esophagitis. An elevated AFP level 2 years after the operation led us to suspect tumor recurrence; however, diagnostic imaging studies showed no evidence of a recurrence or metastases. The serum AFP levels responded well to chemotherapy with transient decreased levels, but continued to rise until finally, 5 years after the operation, adenocarcinoma cells were detected in the pleural effusion. Thus, careful monitoring of the serum AFP levels at regular intervals could be a useful marker to indicate recurrence of esophageal carcinoma.
N Kobayashi; M Ohbu; S Kuroyama; S Kikuchi; H Shimao; H Mitomi; A Kakita
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  31     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2001  
Date Detail:
Created Date:  2001-12-10     Completed Date:  2002-02-28     Revised Date:  2006-08-03    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  915-9     Citation Subset:  IM    
Department of Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
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MeSH Terms
Adenocarcinoma / metabolism*,  surgery
Esophageal Neoplasms / metabolism*,  surgery
Middle Aged
Neoplasm Proteins / biosynthesis*
alpha-Fetoproteins / biosynthesis*
Reg. No./Substance:
0/Neoplasm Proteins; 0/alpha-Fetoproteins

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