Document Detail


Alpha 2-macroglobulin-kallikrein potentiates contact system activity: possible effect in asthma.
MedLine Citation:
PMID:  2440813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bradykinin release, an end product of contact system activation, is thought to play a significant role in the pathophysiology of asthma. We have found an increased level of native alpha 2-macroglobulin-kallikrein (alpha 2M-KK) in asthma plasmas, and have demonstrated increased levels of contact system activity in these plasmas under certain laboratory conditions. We investigated the possible role of alpha 2M-KK as a modulator of the contact system activity. Alpha 2M-KK potentiated the factor XII activation on kaolin and the kallikrein production in a dextran-sulfate-mediated assay. This potentiation presumably involves a proteolytic effect of alpha 2M-KK on high molecular weight kininogen.
Authors:
A M Freyria; E C Lasser; S G Lyon; R A Simon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  83     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-15     Completed Date:  1987-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asthma / blood*,  physiopathology
Dextran Sulfate
Dextrans / pharmacology
Dose-Response Relationship, Drug
Drug Synergism
Factor XII / metabolism*
Factor XIIa
Humans
Kallikreins / analysis,  physiology*
Kaolin / pharmacology
Kininogens / physiology
Methods
Peptide Fragments / metabolism
Prekallikrein / metabolism
alpha-Macroglobulins / analysis,  physiology*
Grant Support
ID/Acronym/Agency:
CA 32851/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Kininogens; 0/Peptide Fragments; 0/alpha 2-macroglobulin-kallikrein complex; 0/alpha-Macroglobulins; 1332-58-7/Kaolin; 9001-30-3/Factor XII; 9004-54-0/Dextrans; 9042-14-2/Dextran Sulfate; 9055-02-1/Prekallikrein; EC 3.4.21.-/Kallikreins; EC 3.4.21.38/Factor XIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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