Document Detail

Alpha 2-macroglobulin and alpha 2-macroglobulin/proteinase complexes in human seminal fluid.
MedLine Citation:
PMID:  1370944     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the broad-spectrum proteinase inhibitor alpha 2-macroglobulin (alpha 2M) and its functional subforms, i.e., free alpha 2M and alpha 2M/proteinase complexes, in human seminal fluid by using specific enzyme immunoassay systems. SETTING: The study has been performed in the Andrology Department of the Dermatology Clinics and the Laboratory of Immunopathology of the Institute of Immunology. PATIENTS, PARTICIPATES: Routine patients attending the Andrology Department. INTERVENTIONS: The data have been obtained without particular interventions before or after collection of seminal fluid. MAIN OUTCOME MEASURES: The aim of the study was to determine whether alpha 2M or alpha 2M/proteinase complexes are present in human seminal fluid. RESULTS: The concentration of total alpha 2M in human seminal fluid ranged from 1 to greater than 1,000 ng/mL, and between 56% and 85% of the inhibitor was complexed with proteinases. CONCLUSIONS: These findings show that alpha 2M and alpha 2M/proteinase complexes have to be considered as functionally relevant biomolecules in male genital tract secretions.
M D Kramer; M M Simon; W Tilgen; H Näher; C W Justus; D Petzoldt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  57     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Institut für Immunologie und Serologie, Heidelberg, Germany.
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MeSH Terms
Endopeptidases / metabolism*
Neutrophils / enzymology
Pancreatic Elastase / metabolism
Semen / metabolism*
alpha-Macroglobulins / chemistry,  metabolism*
Reg. No./Substance:
0/alpha-Macroglobulins; EC 3.4.-/Endopeptidases; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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