Document Detail


Alpha-2 interferon and 5-fluorouracil in advanced colorectal cancer.
MedLine Citation:
PMID:  2205028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 21 untreated patients (5 males, 16 females; median age, 55 years; range, 28-72) with advanced measurable colorectal carcinoma were treated with an association of 5-fluorouracil (1000 mg/weekly) and alpha-2 interferon (three times a week s.c.: 6 x 10(6) U in the 1st month, 9 x 10(6) U in the 2nd month, 12 x 10(6) U in the 3rd month and then 18 x 10(6) U) until maximum response or progression of disease. Sites of disease involved liver in 10 patients, lung in 6, supraclavicular lymph nodes in 3, skin in 1, abdomen in 4, and vagina in 1 patient. Nine responses (42.8%) were documented (4 complete and 5 partial) with metastases confined to the liver, lung, nodes and skin. Median duration of response was 11 months (range, 4-17+) and median survival was 10 months (range, 2-17+). Side effects (fever, flu-like syndrome and leukopenia) required a dose reduction of 5-fluorouracil in 8 patients and interferon in 2 patients.
Authors:
A Fornasiero; O Daniele; C Ghiotto; S M Aversa; P Morandi; M V Fiorentino
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  76     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
Affiliation:
Divisione di Oncologia Medica, U.S.S.L. 21 Padova, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma / drug therapy,  pathology,  therapy*
Clinical Trials as Topic
Colorectal Neoplasms / drug therapy,  pathology,  therapy*
Drug Administration Schedule
Drug Therapy, Combination
Female
Fluorouracil / administration & dosage,  adverse effects,  therapeutic use*
Humans
Interferon Type I, Recombinant / administration & dosage,  adverse effects,  therapeutic use*
Male
Middle Aged
Neoplasm Staging
Chemical
Reg. No./Substance:
0/Interferon Type I, Recombinant; 51-21-8/Fluorouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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