| Alpha 2-adrenoreceptor stimulation inhibits thermogenesis and food intake during glucoprivation in humans. | |
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MedLine Citation:
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PMID: 6148022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noradrenergic central and peripheral nervous system mechanisms for the control of food intake and thermogenesis, respectively, have been described in rats and, to a lesser extent, in humans. To examine further the role of the sympathetic nervous system in energy balance modulation during glucoprivation, the alpha 2-adrenoreceptor agonist clonidine was given to subjects receiving 2-deoxy-D-glucose, a competitive inhibitor of glucose utilization, which induces sympathetic discharge, ingestive behavior, and thermogenesis by initial actions in the central nervous system. Increases in food intake and thermogenesis in association with activation of descending sympathetic outflow during 2-deoxy-D-glucose-induced glucoprivation were totally abolished by clonidine administration. Neither increases in hunger ratings after 2-deoxy-D-glucose infusions nor basal hunger and food intake after sham infusions were decreased by clonidine treatment, which nevertheless reduced thermogenesis under basal conditions. These results clearly indicate that catecholamine-mediated thermogenesis under both stimulated and basal conditions is inhibited by central or peripheral actions of clonidine, presumably at the level of alpha 2-adrenoreceptors. The reduction in food intake brought about by clonidine treatment in subjects undergoing glucoprivic stress may be the result of potentiation of satiation or reduction of hunger during a test meal rather than decreased hunger before a test meal. |
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Authors:
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D A Thompson; L Pénicaud; S L Welle |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-10-24 Completed Date: 1984-10-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R560-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Blood Glucose / analysis Body Temperature Regulation / drug effects* Clonidine / pharmacology* Deoxyglucose / pharmacology Eating / drug effects* Epinephrine / blood Fatty Acids / blood Glucose / deficiency* Humans Hunger / drug effects Male Metabolism / drug effects Norepinephrine / blood Pulse / drug effects Rest |
| Grant Support | |
ID/Acronym/Agency:
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AM-20494/AM/NIADDK NIH HHS; AMHL-00564/AM/NIADDK NIH HHS; RR-00044/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Blood Glucose; 0/Fatty Acids; 154-17-6/Deoxyglucose; 4205-90-7/Clonidine; 50-99-7/Glucose; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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