Alpha 2-adrenergic receptor levels in obstructive and spastic Raynaud's syndrome.

Alpha 2-adrenergic receptor levels in obstructive and spastic Raynaud's syndrome.

MedLine Citation:	PMID: 3025464 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	The present study examines the hypothesis that alterations in the activity of alpha 2-adrenergic receptors (A2R) may underlie the clinical vasospasm seen in patients with Raynaud's syndrome. Platelets were isolated from 13 normal subjects, from 50 patients with vasospastic Raynaud's syndrome, and from 20 patients with obstructive Raynaud's syndrome and A2R levels measured. Binding capacity as determined in femtomoles per milligram of protein (fmol/mg of protein) and affinity were measured by Scatchard plot analysis. In a separate experiment normal human platelets were incubated with either buffer, normal serum, or serum from patients with spastic Raynaud's syndrome and A2R levels were measured. A2R levels in normal subjects averaged 112 +/- 18 fmol/mg; in the patients with spastic Raynaud's syndrome, 191 +/- 14 fmol/mg, p less than 0.01; and in the patients with obstructive Raynaud's syndrome, 164 +/- 31 fmol/mg, p greater than 0.05 (ns). Of the patients with spastic Raynaud's syndrome, 26% had values that were less than the mean value of the normal subjects (69 +/- 7 fmol/mg, p less than 0.05). The A2R levels decreased after incubation with serum from patients who had spastic Raynaud's syndrome by 17.4 +/- 3.1 fmol/mg (p less than 0.05). These results indicate that most patients with vasospastic Raynaud's syndrome have increased platelet A2R levels, which may constitute a primary pathophysiologic abnormality underlying this condition. The presence of subnormal A2R levels in a portion of the patients and the finding of a decrease in measurable A2R levels after incubation in serum from patients with spastic Raynaud's syndrome suggests the possibility of receptor modulation as a mechanism for increased cellular receptor synthesis.

Authors:	J M Edwards; E S Phinney; L M Taylor; E J Keenan; J M Porter
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Publication Detail:	Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal Detail:	Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 5 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1987 Jan
Date Detail:	Created Date: 1987-02-18 Completed Date: 1987-02-18 Revised Date: 2007-11-14
Medline Journal Info:	Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES
Other Details:	Languages: eng Pagination: 38-45 Citation Subset: IM
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MeSH Terms
Descriptor/Qualifier:	Blood Platelets / analysis* Humans Raynaud Disease / etiology, metabolism, physiopathology Receptors, Adrenergic, alpha / analysis
Grant Support
ID/Acronym/Agency:	RR-00334/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:	0/Receptors, Adrenergic, alpha

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