Document Detail


Alpha 1-antitrypsin phenotypes in patients with abdominal aortic aneurysms.
MedLine Citation:
PMID:  2214739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The alpha 1-antitrypsin phenotypes were determined in 47 patients with abdominal aortic aneurysms. The MM phenotype was present in 85%, the MS phenotype in 4%, the MZ phenotype in 11%, and the ZZ phenotype not present in any patients. The MZ phenotype occurred significantly more often in patients with aneurysms than would be expected in the general population. The current data would support a genetic mechanism of either autosomal-dominant or multifactorial influences but not an X-linked mechanism for families with a history of abdominal aortic aneurysms.
Authors:
J R Cohen; I Sarfati; L Ratner; D Tilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  49     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-16     Completed Date:  1990-11-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  319-21     Citation Subset:  IM    
Affiliation:
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
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MeSH Terms
Descriptor/Qualifier:
Aorta, Abdominal
Aortic Aneurysm / genetics*
Humans
Phenotype*
alpha 1-Antitrypsin / genetics*
Chemical
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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