Document Detail

Alpha 1-antitrypsin in patients with hepatocellular carcinoma and chronic active hepatitis.
MedLine Citation:
PMID:  6258829     Owner:  NLM     Status:  MEDLINE    
Forty-seven Italian patients suffering from hepatocellular carcinoma (HCC) and 58 patients with chronic active hepatitis (CAH) were screened for alpha 1-antitrypsin (alpha 1 AT) levels and types and compared with a previously screened healthy Italian population. Serum alpha 1 AT concentrations were significantly raised among the HCC patients compared to the controls, whereas the CAH group showed no differences. The incidence of non-M phenotypes (MS, MZ and S) is significantly higher in patients with HCC than in the CAH group and the controls. The mean age of HCC patients with a non-M phenotype is significantly lower than the mean age of HCC patients with an M phenotype.
S Fargion; E C Klasen; F Lalatta; G Sangalli; M Tommasini; G Fiorelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  19     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Hepatocellular / blood,  genetics*
Chronic Disease
Gene Frequency
Hepatitis / blood,  genetics*
Liver Neoplasms / blood,  genetics*
Middle Aged
alpha 1-Antitrypsin / genetics*
Reg. No./Substance:
0/alpha 1-Antitrypsin

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