| Alpha 1-antitrypsin deficiency and pregnancy. | |
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MedLine Citation:
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PMID: 8540927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alpha1-antitrypsin deficiency is an inherited pulmonary disorder which results from a deficiency of a major plasma protease inhibitor. The onset and severity of symptoms vary widely and depend on the genotype and whether the patient smokes cigarettes. Alpha1-antitrypsin in pregnancy has only been previously reported twice. Our patient had a functional serum alpha1-antitrypsin level which was 15% of normal but was clinically asymptomatic and she did not smoke. Her genotype revealed a non-ZZ pattern. Her obstetric history was complicated by preterm labor in each of her five ongoing pregnancies. Alpha1-antitrypsin deficiency is inherited via two codominant autosomal genes. Although there is great variability in severity of disease, seriously affected patients may have emphysema and hepatic abnormalities. Patients with non-ZZ genotypes or who are heterozygotes may have favorable pregnancy outcomes. |
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Authors:
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J A Kuller; V L Katz; M C McCoy; C L Bristow |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 12 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1996-02-13 Completed Date: 1996-02-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 303-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill 27599-7570, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Genotype Humans Infant, Newborn Obstetric Labor, Premature Pregnancy Pregnancy Complications* alpha 1-Antitrypsin / genetics alpha 1-Antitrypsin Deficiency* |
| Chemical | |
Reg. No./Substance:
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0/alpha 1-Antitrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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