Document Detail

Alpha 1-antitrypsin deficiency and pregnancy.
MedLine Citation:
PMID:  8540927     Owner:  NLM     Status:  MEDLINE    
Alpha1-antitrypsin deficiency is an inherited pulmonary disorder which results from a deficiency of a major plasma protease inhibitor. The onset and severity of symptoms vary widely and depend on the genotype and whether the patient smokes cigarettes. Alpha1-antitrypsin in pregnancy has only been previously reported twice. Our patient had a functional serum alpha1-antitrypsin level which was 15% of normal but was clinically asymptomatic and she did not smoke. Her genotype revealed a non-ZZ pattern. Her obstetric history was complicated by preterm labor in each of her five ongoing pregnancies. Alpha1-antitrypsin deficiency is inherited via two codominant autosomal genes. Although there is great variability in severity of disease, seriously affected patients may have emphysema and hepatic abnormalities. Patients with non-ZZ genotypes or who are heterozygotes may have favorable pregnancy outcomes.
J A Kuller; V L Katz; M C McCoy; C L Bristow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  12     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill 27599-7570, USA.
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MeSH Terms
Infant, Newborn
Obstetric Labor, Premature
Pregnancy Complications*
alpha 1-Antitrypsin / genetics
alpha 1-Antitrypsin Deficiency*
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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