Document Detail

Alpha-1-antitrypsin and chronic bronchitis in adult Nigerians.
MedLine Citation:
PMID:  2127999     Owner:  NLM     Status:  MEDLINE    
Alpha-1-antitrypsin (A1AT) serum levels and phenotypes were determined in 49 Nigerians with chronic bronchitis and 100 normal controls. The A1AT phenotypes encountered were PiMM, 69% in chronic bronchitics, 98% in controls; PiMZ, 23% in chronic bronchitics, 1% in controls; PiLM, 2% in chronic bronchitics, 1% in controls. There were three patients (6%) with the homozygous-deficient phenotype PiZZ. Spirometry confirmed obstructive ventilatory pattern in the patients with chronic bronchitis, and the difference in the values obtained between the patients and controls was statistically significant (P less than 0.01). Serum A1AT levels were within the normal range of 1.4-2.7 g/l in all except the three patients with PiZZ. There was no significant difference in the A1AT serum levels between patients with chronic bronchitis and control subjects with the PiMM phenotype; tests of significance were not possible for the other phenotypes because of the small number of subjects. The observation of PiZZ in 6% of our patients with chronic bronchitis is in support of screening of this category of patients. Replacement therapy with alpha-1-antitrypsin inhibitor is currently under investigation and may be worthwhile in these patients if detected early.
A A Awotedu; A B Adelaja
Related Documents :
25299619 - General immune status and oral microbiology in patients with different forms of periodo...
2302769 - Scc antigen measured in malignant and nonmalignant diseases.
9444429 - A multicenter study on insulin-like growth factor-i serum levels in children with chron...
18663529 - Squamous cell carcinoma antigen in lung cancer and nonmalignant respiratory diseases.
20546739 - Lysophosphatidic acid is a potential mediator of cholestatic pruritus.
3318049 - Serum thymidine kinase and beta-2 microglobulin in monoclonal gammopathies.
1810979 - Association of autoimmunity and cicatricial pemphigoid: is there an immunogenetic basis?
19491829 - Comparison of the degree of duodenogastroesophageal reflux and acid reflux between pati...
10208209 - Hypoalbuminemia as a cause of pleural effusions.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  19     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bronchitis / blood,  epidemiology,  genetics*
Chronic Disease
Middle Aged
Nigeria / epidemiology
alpha 1-Antitrypsin / chemistry*,  genetics
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alpha-1-antitrypsin levels and prevalence of Pi variant phenotypes in adult Nigerian asthmatics.
Next Document:  Plasmid screening amongst Aeromonas species and Plesiomonas shigelloides isolated from subjects with...