Document Detail

Alpha-1-antitrypsin and chronic bronchitis in adult Nigerians.
MedLine Citation:
PMID:  2127999     Owner:  NLM     Status:  MEDLINE    
Alpha-1-antitrypsin (A1AT) serum levels and phenotypes were determined in 49 Nigerians with chronic bronchitis and 100 normal controls. The A1AT phenotypes encountered were PiMM, 69% in chronic bronchitics, 98% in controls; PiMZ, 23% in chronic bronchitics, 1% in controls; PiLM, 2% in chronic bronchitics, 1% in controls. There were three patients (6%) with the homozygous-deficient phenotype PiZZ. Spirometry confirmed obstructive ventilatory pattern in the patients with chronic bronchitis, and the difference in the values obtained between the patients and controls was statistically significant (P less than 0.01). Serum A1AT levels were within the normal range of 1.4-2.7 g/l in all except the three patients with PiZZ. There was no significant difference in the A1AT serum levels between patients with chronic bronchitis and control subjects with the PiMM phenotype; tests of significance were not possible for the other phenotypes because of the small number of subjects. The observation of PiZZ in 6% of our patients with chronic bronchitis is in support of screening of this category of patients. Replacement therapy with alpha-1-antitrypsin inhibitor is currently under investigation and may be worthwhile in these patients if detected early.
A A Awotedu; A B Adelaja
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African journal of medicine and medical sciences     Volume:  19     ISSN:  0309-3913     ISO Abbreviation:  Afr J Med Med Sci     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-03     Completed Date:  1991-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801013     Medline TA:  Afr J Med Med Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Department of Medicine, University College Hospital, Ibadan, Nigeria.
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MeSH Terms
Bronchitis / blood,  epidemiology,  genetics*
Chronic Disease
Middle Aged
Nigeria / epidemiology
alpha 1-Antitrypsin / chemistry*,  genetics
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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