Document Detail

Alopecia attributed to neoplastic ovarian tissue in two ferrets.
MedLine Citation:
PMID:  12784857     Owner:  NLM     Status:  MEDLINE    
Ferrets with adrenal gland dysfunction have alopecia as their most common clinical sign of disease. Two cases of alopecia in neutered female ferrets are reported that were associated instead with neoplastic tissue found at the site of an ovarian pedicle. Androstenedione and 17-hydroxyprogesterone, but not estradiol, concentrations were high in both ferrets. Following surgical resection of the abnormal tissue in one ferret, the high hormone values decreased quickly and hair regrowth ensued. In both cases, histologic examination revealed features consistent with classical sex cord-stromal (gonadostromal) tumors: prominent spindle cells, along with polyhedral epithelial cells and cells with vacuolated cytoplasm. Although similiar cell types have been described in the adrenal glands of ferrets with adrenal-associated endocrinopathy, an ovarian origin for the current neoplasms is considered likely on the basis of their anatomic location; accessory adrenal tissue has only been described close to an adrenal gland or in the cranial perirenal fat of ferrets. Immunohistochemical analysis, using an antibody against Mullerian-inhibiting substance, failed to prove definitively the source of the steroidogenic cells.
Mary M Patterson; Arlin B Rogers; Mark D Schrenzel; Robert P Marini; James G Fox
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Comparative medicine     Volume:  53     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-06-04     Completed Date:  2003-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Division of Comparative Medicine, Massachuetts Institute of Technology, Cambridge 02139, USA.
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MeSH Terms
17-alpha-Hydroxyprogesterone / blood
Alopecia / complications,  pathology,  veterinary*
Androstenedione / blood
Granulosa Cell Tumor / complications,  pathology,  veterinary*
Immunohistochemistry / veterinary
Ovarian Neoplasms / complications,  pathology,  veterinary*
Grant Support
Reg. No./Substance:
63-05-8/Androstenedione; 68-96-2/17-alpha-Hydroxyprogesterone

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