| Alopecia areata: topical immunotherapy treatment with diphencyprone. | |
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MedLine Citation:
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PMID: 18005118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND Topical immunotherapy with diphencyprone (DPCP) is considered the most effective treatment of alopecia areata (AA). OBJECTIVE: To assess the efficacy of DPCP in the treatment of extensive or long-lasting AA in Greek patients. METHODS: Sixty-four patients with extensive and/or long-lasting AA were sensitized with 2% diphencyprone. During each weekly subsequent visit, patients were treated with gradually denser concentrations adjusted in order to maintain erythema and itch on the patient's scalp for 48 h. Patients' hair re-growth was evaluated every 3 months for 2 years. RESULTS: Forty-five patients responded among the 54 completing therapy (83.3%). Initial response was observed 3.48 +/- 1.05 months after the initial treatment. Twenty patients among the responders achieved a grade 4 response, 15 patients achieved grade 3, 9 patients achieved grade 2, and 1 patient achieved a grade 1 response. The mean duration of treatment until maximum response was 6.14 +/- 1.48 months. Thirty-one patients (68.9%) had a relapse during follow-up and were treated again. The only adverse event among patients completing therapy was contact dermatitis of the face or neck (9 of 54) that resolved after topical corticosteroid application within 7 days. Statistical analysis did not establish any association among duration of AA, age, gender, atopic diathesis, nail involvement and presence of thyroid antibodies with response to treatment. CONCLUSION: Treatment of Greek patients with AA with diphencyprone presents high response rates similar to those reported by previous studies. The treatment is adequately tolerated by most of the patients, and they are willing to repeat it in cases of relapse. |
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Authors:
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G Avgerinou; S Gregoriou; D Rigopoulos; A Stratigos; D Kalogeromitros; A Katsambas |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2007-11-12 |
Journal Detail:
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Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: 22 ISSN: 1468-3083 ISO Abbreviation: J Eur Acad Dermatol Venereol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-13 Completed Date: 2008-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 320-3 Citation Subset: IM |
Affiliation:
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1st Academic Department of Dermatology, University of Athens Medical School, A Sygros Hospital, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Alopecia Areata / drug therapy*, immunology, pathology Cyclopropanes / administration & dosage*, adverse effects Dose-Response Relationship, Drug Female Hair / drug effects, growth & development Humans Immunotherapy / methods* Male Middle Aged Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cyclopropanes; 886-38-4/diphenylcyclopropenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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