Document Detail

Alopecia areata. A pathological study of nonresponder patients.
MedLine Citation:
PMID:  8030769     Owner:  NLM     Status:  MEDLINE    
Fourteen patients, four male and 10 female and ranging in age from 11 to 57 years, affected by longstanding alopecia areata that had not responded to sensitizing treatments, were submitted to scalp biopsy. Five patients had alopecia totalis and nine had alopecia universalis. The biopsy was performed on a scalp area that had been bald for > or = 1 year. We distinguished four distinct pathological patterns, which we termed "established bald patch," "early regrowth," "telogen," and "scarring," in four, seven, one, and two patients, respectively. Our study shows that, from a pathological point of view, nonresponder patients constitute a heterogeneous population. The pathological study of the scalp helps predict therapeutic failure only in the small proportion of nonresponder patients that shows a scarring pathological pattern.
P A Fanti; A Tosti; F Bardazzi; L Guerra; R Morelli; N Cameli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  16     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-11     Completed Date:  1994-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
Department of Dermatology, University of Bologna, Italy.
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MeSH Terms
Alopecia Areata / drug therapy,  pathology*
Cyclobutanes / therapeutic use
Drug Resistance
Middle Aged
Skin / pathology
Reg. No./Substance:
0/Cyclobutanes; 2892-62-8/squaric acid dibutyl ester

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