Document Detail

Almost everyone over 50 should be put on a statin to reduce the risk of cardiovascular disease: A contrarian view.
MedLine Citation:
PMID:  24003653     Owner:  NLM     Status:  In-Process    
3-Hydroxy-3-methyl-glutarylCoA reductase inhibitors, or statins, are a mainstay in the treatment of patients with established coronary artery disease (CAD) because of their proven efficacy in reducing cardiovascular death, myocardial infarction, and coronary revascularization procedures in this patient population. Statin therapy has also proven successful in the primary prevention of CAD. However, the absolute reduction in cardiovascular events is lower in primary prevention than in secondary prevention trials, and many of the primary prevention trials enrolled a significant number of patients with established cardiovascular disease and/or other high-risk features, such as diabetes mellitus. For these reasons we do not recommend widespread treatment of the general adult population with a statin. Rather, we advocate a strategy which involves collection of standard clinical data and the use of validated risk-prediction tools to stratify patient risk and limit initiation of a statin to those who are more likely to benefit from such therapy.
Mayank Mittal; William P Fay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Missouri medicine     Volume:  110     ISSN:  0026-6620     ISO Abbreviation:  Mo Med     Publication Date:    2014 Jul-Aug
Date Detail:
Created Date:  2013-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400744     Medline TA:  Mo Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-41     Citation Subset:  IM    
Department of Internal Medicine, University of Missouri School of Medicine, USA.
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