Document Detail


Almitrine and the peripheral ventilatory response to CO2 in hyperoxia and hypoxia.
MedLine Citation:
PMID:  2515570     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of almitrine bismesylate (initial intravenous dose 0.6 mg.kg-1 followed by continuous infusion of 0.4 mg.kg-1.h-1) on the ventilatory response to CO2 during hyperoxia and hypoxia were determined in 6 anaesthetized cats with the use of the dynamic end-tidal CO2 forcing technique. It was found that almitrine almost doubled the peripheral ventilatory sensitivity to CO2 during hyperoxia (mean PETO2 45.6 kPa) and also during mild hypoxia (mean PETO2 8.7 kPa). The apnoeic threshold (B) was in both cases shifted to substantially lower values than those of the control measurements. No significant effects of almitrine were found on the central ventilatory sensitivity to CO2 either during hyperoxia or during hypoxia. It is argued that the decrease of the apnoeic threshold may be due to an inhibitory effect of almitrine on the carotid body dopaminergic activity, and that the increase of the sensitivity to CO2 stems from a "hypoxia mimetic" mechanism.
Authors:
C N Olievier; A Berkenbosch; J DeGoede
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  78     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  391-402     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Almitrine / pharmacology*
Analysis of Variance
Animals
Anoxia / physiopathology*
Carbon Dioxide / pharmacology*
Cats
Chemoreceptor Cells / physiopathology
Female
Male
Oxygen / metabolism*
Reflex / physiology
Respiration / drug effects*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 27469-53-0/Almitrine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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