Document Detail


Alloxan diabetes: a discovery, albeit a minor one.
MedLine Citation:
PMID:  12434795     Owner:  HMD     Status:  MEDLINE    
Abstract/OtherAbstract:
The remarkable discovery that a single injection of alloxan can produce diabetes mellitus in laboratory animals was made in 1942, in Glasgow, by John Shaw Dunn and Norman McLetchie. Alloxan, a simple nitrogenous organic compound, had made a long journey to get to Glasgow - it belongs to the very origins of systematic organic chemistry - from Germany. It was discovered by the fathers of this science, Frederick Wöhler and Justin J. Liebig, beginning with the synthesis of urea in 1828, then of uric acid and the naming of some 13 derivatives of uric acid, including alloxan. The name 'alloxan,' given by Wöhler and Liebig, is recorded as being derived from a combination of allantoin (a product of uric acid among others excreted by the fetus into the allantois) and 'oxalsaüre' (oxaluric acid derived from oxalic acid and urea, found in urine).
Authors:
N G McLetchie
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Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  The journal of the Royal College of Physicians of Edinburgh     Volume:  32     ISSN:  1478-2715     ISO Abbreviation:  J R Coll Physicians Edinb     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-15     Completed Date:  2002-12-11     Revised Date:  2008-03-26    
Medline Journal Info:
Nlm Unique ID:  101144324     Medline TA:  J R Coll Physicians Edinb     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  134-42     Citation Subset:  Q    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Laboratory*
Diabetes Mellitus / history*
Diabetes Mellitus, Experimental / history*
History, 19th Century
History, 20th Century
History, 21st Century
Scotland
Personal Name Subject
Personal Name Subject:
John Shaw Dunn; Norman McLetchie

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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