Document Detail

Alloxan diabetes: a discovery, albeit a minor one.
MedLine Citation:
PMID:  12434795     Owner:  HMD     Status:  MEDLINE    
The remarkable discovery that a single injection of alloxan can produce diabetes mellitus in laboratory animals was made in 1942, in Glasgow, by John Shaw Dunn and Norman McLetchie. Alloxan, a simple nitrogenous organic compound, had made a long journey to get to Glasgow - it belongs to the very origins of systematic organic chemistry - from Germany. It was discovered by the fathers of this science, Frederick Wöhler and Justin J. Liebig, beginning with the synthesis of urea in 1828, then of uric acid and the naming of some 13 derivatives of uric acid, including alloxan. The name 'alloxan,' given by Wöhler and Liebig, is recorded as being derived from a combination of allantoin (a product of uric acid among others excreted by the fetus into the allantois) and 'oxalsaüre' (oxaluric acid derived from oxalic acid and urea, found in urine).
N G McLetchie
Related Documents :
12669155 - Characteristics of nanobacteria and their possible role in stone formation.
20349345 - Serum uric acid does not predict cardiovascular or all-cause mortality in type 2 diabet...
15104415 - Molecular biological considerations in cerebral vasospasm following aneurysmal subarach...
16220575 - Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects.
5810065 - A study of the carbohydrate present in three type k macroglobulins.
569425 - Amino acid supplementation of isolated soybean protein in milk replacers for preruminan...
Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  The journal of the Royal College of Physicians of Edinburgh     Volume:  32     ISSN:  1478-2715     ISO Abbreviation:  J R Coll Physicians Edinb     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-15     Completed Date:  2002-12-11     Revised Date:  2008-03-26    
Medline Journal Info:
Nlm Unique ID:  101144324     Medline TA:  J R Coll Physicians Edinb     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  134-42     Citation Subset:  Q    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Laboratory*
Diabetes Mellitus / history*
Diabetes Mellitus, Experimental / history*
History, 19th Century
History, 20th Century
History, 21st Century
Personal Name Subject
Personal Name Subject:
John Shaw Dunn; Norman McLetchie

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Blepharospasm: recent advances.
Next Document:  Plants against malaria. Part 1: Cinchona or the Peruvian bark.