| Allostery of the two-state model of hemoglobin studied by ECEPP energy minimization. | |
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MedLine Citation:
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PMID: 16514594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, a powerful parallel-vector processor became available for molecular science. A new FORTRUN program was coded to treat the whole hemoglobin molecule with twofold symmetry. Using the X-ray coordinates of deoxyhemoglobin and oxyhemoglobin, minimum energy conformations were obtained for both the T-state and the R-state on the two-state model of allostery. From them, further energy minimization was performed with simple perturbation to bring the proximal region close to the heme group instead of oxygen binding, and the structural changes and energy changes were investigated. The difference of calculated energy changes between T and R was semiquantitatively in agreement with the experimental value 2.7 kcal/mol for one oxygen binding. When the perturbation was exerted on the alpha-subunits, the energy change within the perturbed alpha-subunits in the T-state gave a main contribution, and in the R-state, the structural changes of the alpha-subunits were specifically large. When the perturbation was exerted on the beta-subunits, the intersubunit interaction energy between alpha1 and beta2 (alpha2 and beta1) was dominant in the difference of the energy changes between T and R. |
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Authors:
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Yasunobu Seno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computational chemistry Volume: 27 ISSN: 0192-8651 ISO Abbreviation: J Comput Chem Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-24 Completed Date: 2007-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9878362 Medline TA: J Comput Chem Country: United States |
Other Details:
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Languages: eng Pagination: 701-10 Citation Subset: IM |
Affiliation:
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Research Institute of Science and Technology, Tokai University, Hiratsuka-si Kitakaname 1117, Kanagawa-ken 259-1292, Japan. yaseno@star.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allosteric Regulation Crystallography, X-Ray Heme / chemistry Hemoglobins / chemistry*, metabolism* Models, Molecular* Protein Structure, Tertiary Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 14875-96-8/Heme |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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