Document Detail


Allosteric regulation of the conformational dynamics of a cavitand receptor.
MedLine Citation:
PMID:  16898795     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
[reaction: see text] Inspired by allostery in nature, we synthesized cavitand 1 and investigated regulation of its conformational dynamics. Quantitative 1H NMR studies have revealed that the rate of the conformational isomerization of 1 can be modulated using the external addition of acid. As 1 maintains its vase-like conformation in an acidic environment, ample opportunities for controlling the kinetics of molecular recognition, and thus reactivity, in this and related receptors have arisen.
Authors:
Zhiqing Yan; Yuning Chang; Dennis Mayo; Veselin Maslak; Shijing Xia; Jovica D Badjić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Organic letters     Volume:  8     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2007-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3697-700     Citation Subset:  -    
Affiliation:
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
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