| Allopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure. | |
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MedLine Citation:
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PMID: 15894768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study whether the effect of allopurinol on improvement of endothelial dysfunction in chronic heart failure (CHF) translates into improved exercise capacity and to examine whether allopurinol also improves B-type natriuretic peptide (BNP), the other important prognostic marker of CHF. DESIGN: Randomised, double blind, placebo controlled crossover trial. SETTING: Teaching hospital. PATIENTS: 50 patients with CHF (New York Heart Association functional classes II and III) were recruited. INTERVENTIONS: 50 patients with CHF were randomly assigned to three months' treatment with allopurinol (300 mg/day) or placebo. At two and three months into treatment, they underwent a modified Bruce exercise protocol and a six minute walk test. Blood was taken for BNP and haemoglobin analysis. RESULTS: Neither exercise test was altered by allopurinol. However, plasma BNP concentrations fell significantly (p = 0.035) with allopurinol (11.9 pmol/l) versus placebo (14.4 pmol/l). Haemoglobin concentrations also fell highly significantly with allopurinol (p = 0.001). CONCLUSIONS: An important negative finding is that despite high hopes for it, allopurinol had no effect on exercise capacity in CHF. On the other hand, allopurinol did reduce BNP, which is the best available surrogate marker for prognosis in CHF. |
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Authors:
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A D Gavin; A D Struthers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 91 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-16 Completed Date: 2005-07-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 749-53 Citation Subset: AIM; IM |
Affiliation:
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Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, Dundee, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Allopurinol / therapeutic use* Analysis of Variance Biological Markers / blood Chronic Disease Cross-Over Studies Double-Blind Method Endothelium, Vascular / drug effects Enzyme Inhibitors / therapeutic use* Exercise Tolerance / drug effects Female Heart Failure / blood, drug therapy*, enzymology Hemoglobins / metabolism* Humans Male Natriuretic Peptide, Brain / blood* Ventricular Dysfunction, Left / blood, drug therapy*, enzymology Xanthine Oxidase / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Enzyme Inhibitors; 0/Hemoglobins; 114471-18-0/Natriuretic Peptide, Brain; 315-30-0/Allopurinol; EC 1.17.3.2/Xanthine Oxidase |
| Comments/Corrections | |
Comment In:
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Heart. 2005 Jun;91(6):707-9
[PMID:
15894755
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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