| Allopurinol in dermatology. | |
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MedLine Citation:
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PMID: 20509717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Off-label use is common in dermatology, and is inevitable for rare cutaneous diseases such as perforating dermatosis. Allopurinol is traditionally considered to be a drug for hyperuricemia only, but the recent demonstration of its efficacy in congestive heart failure has spurred renewed interest in its application in other clinical specialties. In dermatology, allopurinol is best known for its severe cutaneous adverse reactions. Recent genomic studies conducted in Taiwan have discovered useful HLA markers for determining the susceptibility of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with allopurinol. Allopurinol has also been used in a number of dermatologic disorders including acquired reactive perforating collagenosis, sarcoidosis, psoriasis and granulomas caused by methacrylate microspheres, silicon and tattoos. Allopurinol may express its therapeutic effects via its antioxidation or anti-inflammatory properties, or its ability to improve vascular function. |
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Authors:
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Tsen-Fang Tsai; Ting-Yu Yeh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of clinical dermatology Volume: 11 ISSN: 1175-0561 ISO Abbreviation: Am J Clin Dermatol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100895290 Medline TA: Am J Clin Dermatol Country: New Zealand |
Other Details:
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Languages: eng Pagination: 225-32 Citation Subset: IM |
Affiliation:
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Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan. tftsai@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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adverse effects,
therapeutic use* Animals Dermatologic Agents / adverse effects, therapeutic use* Drug Eruptions / etiology Drug Interactions Epidermal Necrolysis, Toxic / etiology Gout Suppressants / adverse effects, therapeutic use Humans Off-Label Use Skin Diseases / drug therapy*, physiopathology Stevens-Johnson Syndrome / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Gout Suppressants; 315-30-0/Allopurinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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