Document Detail


Allopurinol hepatotoxicity. Case report and literature review.
MedLine Citation:
PMID:  921828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant hepatotoxicity due to allopurinol seems to be rare. Only 6 such cases have been recorded in the literature. The clinical and histopathologic findings of allopurinol-induced liver injury are variable in the previously reported cases. Described herein is another patient with allopurinol hepatotoxicity. Of interest is the similar histopathology between the present case and the two previously reported cases of allopurinol-induced granulomatous hepatitis; thus this is the third such recorded case. Allopurinol should be suspected when liver abnormalities occur following use of this drug.
Authors:
S K Chawla; H D Patel; G R Parrino; J Soterakis; P A Lopresti; W A D'Angelo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  20     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:    1977 Nov-Dec
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1546-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Allopurinol / adverse effects*,  therapeutic use
Arthritis / drug therapy
Biopsy
Drug-Induced Liver Injury / etiology*,  pathology
Gout / drug therapy
Humans
Liver / pathology
Liver Function Tests
Male
Chemical
Reg. No./Substance:
315-30-0/Allopurinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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