| Allopurinol as a potential therapeutic agent for recurrent herpes labialis. | |
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MedLine Citation:
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PMID: 12968636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrent herpes labialis (RHL) occurs in up to 40% of the population. Although the disease is usually self-limiting, patients seek treatment because of the significant pain and visibility of the lesion. Xanthine oxidase inhibitors (XOI) have been reported to have a potent antiviral effect against influenza-A virus. We examined the effect of the systemic xanthine oxidase inhibitor, allopurinol, on RHL duration of illness, severity of symptoms, number and frequency of recurrence during a 4-year follow up period in Egyptian patients. Duration of illness was shortened by about 25%, early disappearance of pain and other symptoms occurred. Also, aborted episodes were noticed when allopurinol was given just after beginning of common colds, at the prodromal stage of RHL or during severe stress conditions. Patients receiving 3 courses of treatment had markedly decreased recurrences during the follow up period. Ex vivo experiments to examine virus-induced plaque formation on Vero cells in the absence or presence of different concentrations of the drug could not prove any direct anti herpetic effect of the drug. However, allopurinol seems to be safe and effective in reducing duration of RHL and to abort lesion or prevent its appearance in treated patients even when they experience immunosuppressive conditions. |
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Authors:
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Mohamed A El-Farrash; Jilan M Youssef; Shaymaa E El-Mongy |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of medical and dental sciences Volume: 50 ISSN: 1342-8810 ISO Abbreviation: J. Med. Dent. Sci. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-09-12 Completed Date: 2003-11-03 Revised Date: 2010-04-12 |
Medline Journal Info:
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Nlm Unique ID: 9717112 Medline TA: J Med Dent Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 147-54 Citation Subset: D; IM |
Affiliation:
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Department of Medical Microbiology & Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. mfarash@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allopurinol / pharmacology, therapeutic use* Animals Antiviral Agents / pharmacology, therapeutic use* Cercopithecus aethiops Enzyme Inhibitors / pharmacology, therapeutic use* Female Herpes Labialis / drug therapy* Herpesvirus 1, Human / drug effects Humans Male Middle Aged Recurrence / prevention & control Vero Cells |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Enzyme Inhibitors; 315-30-0/Allopurinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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