Document Detail

Allometry of left ventricular myocardial innervation.
MedLine Citation:
PMID:  24325466     Owner:  NLM     Status:  Publisher    
Body mass (BM) of terrestrial mammalian species ranges from a few grams in the case of the Etruscan shrew to a few tonnes for an elephant. The mass-specific metabolic rate, as well as heart rate, decrease with increasing BM, whereas heart mass is proportional to BM. In the present study, we investigated the scaling behaviour of several compartments of the left ventricular myocardium, notably its innervation, capillaries and cardiomyocytes. Myocardial samples were taken from 10 mammalian species with BM between approximately 2 g and 900 kg. Samples were analysed by design-based stereology and electron microscopy and the resulting data were subjected to linear regression and correlation analyses. The total length of nerve fibres (axons) in the left ventricle increased from 0.017 km (0.020 km) in the shrew to 7237 km (13 938 km) in the horse. The innervation density was similar among species but the mean number of axons per nerve fibre profile increased with rising BM. The total length of capillaries increased from 0.119 km (shrew) to 10 897 km (horse). The volume of cardiomyocytes was 0.017 cm(3) in the shrew and 1818 cm(3) in the horse. Scaling of the data against BM indicated a higher degree of complexity of the axon tree in larger animals and an allometric relationship between total length of nerve fibres/axons and BM. In contrast, the density of nerve fibres is independent of BM. It seems that the structural components of the autonomic nervous system in the heart are related to BM and heart mass rather than to functional parameters such as metabolic rate.
Julia Schipke; Terry M Mayhew; Christian Mühlfeld
Related Documents :
18271846 - Long-term outcomes of transposed basilic vein arteriovenous fistulae.
8283606 - The short- and long-term prognosis for acute myocardial infarction after emergency coro...
3290056 - Cardiac disorders: a guide to assessing risk in the elderly.
7127346 - A polygraph study of ischemic heart disease: short-term prognosis of acute myocardial i...
12554056 - Evaluation of point-of-care test systems using the new definition of myocardial infarct...
7628026 - Optimal placement of cvp catheter in paediatric cardiac patients.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-10
Journal Detail:
Title:  Journal of anatomy     Volume:  -     ISSN:  1469-7580     ISO Abbreviation:  J. Anat.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Anatomical Society.
Institute of Functional and Applied Anatomy, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Etiology, clinical outcome, and laboratory features in children with neutropenia: Analysis of 104 ca...
Next Document:  Elevated levels of Extracellular Heat Shock Protein 72 (eHSP72) are positively correlated with insul...