| Allometric prediction of the human pharmacokinetic parameters for naveglitazar. | |
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MedLine Citation:
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PMID: 19007045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compounds that belong to the class known as dual (alpha,gamma) peroxisome proliferator-activated receptors (PPARs) show interesting pharmacological properties--regulation of blood glucose, fatty acids, and lipid parameters. Using the recently published preclinical data of naveglitazar, an allometric method was used to predict the human pharmacokinetic parameters (CL/F and Vss/F). The predicted parameters were compared to observed/predicted values of other important dual (a,y) PPAR compounds. The allometry data suggested that naviglitazar (CL/F) was at least 4 times faster than that of ragaglitazar, while the Vss was either equal to or 40% lower as compared to that of ragaglitazar. |
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Authors:
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Preeti Ahlawat; Nuggehally R Srinivas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of drug metabolism and pharmacokinetics Volume: 33 ISSN: 0378-7966 ISO Abbreviation: Eur J Drug Metab Pharmacokinet Publication Date: 2008 Jul-Sep |
Date Detail:
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Created Date: 2008-11-14 Completed Date: 2008-12-16 Revised Date: 2011-02-02 |
Medline Journal Info:
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Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: Switzerland |
Other Details:
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Languages: eng Pagination: 187-90 Citation Subset: IM |
Affiliation:
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Global Drug Development, ClinTec (India) International Pvt Ltd, Bangalore 560 078, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Evaluation, Preclinical Humans Mice Models, Biological* PPAR alpha / agonists PPAR gamma / agonists Phenylpropionates / pharmacokinetics*, pharmacology Predictive Value of Tests Rabbits Rats |
| Chemical | |
Reg. No./Substance:
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0/PPAR alpha; 0/PPAR gamma; 0/Phenylpropionates; 0/naveglitazar |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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