| Allometric hemodynamic analysis of isolated systolic hypertension and aging. | |
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MedLine Citation:
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PMID: 18008162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance. |
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Authors:
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John K-J Li; Ying Zhu; Dorene O'Hara; Kenneth Khaw |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular engineering (Dordrecht, Netherlands) Volume: 7 ISSN: 1567-8822 ISO Abbreviation: Cardiovasc Eng Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-14 Completed Date: 2008-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101132083 Medline TA: Cardiovasc Eng Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Affiliation:
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Cardiovascular Engineering Labs, Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd, Piscataway, NJ 08854, USA. jli@biomed.rutgers.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Computer Simulation Hemodynamics / physiology* Humans Hypertension / physiopathology* Middle Aged Models, Cardiovascular* Systole* Vascular Resistance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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