Document Detail

Allometric hemodynamic analysis of isolated systolic hypertension and aging.
MedLine Citation:
PMID:  18008162     Owner:  NLM     Status:  MEDLINE    
Isolated systolic hypertension (ISH) is prevalent in the elderly and the contributing factors are predominantly vascular in origin. We previously showed that the hemodynamic manifestation of ISH is the result of a concurrently mild increase in peripheral resistance with a large reduction in arterial compliance or greatly increased vascular stiffness. Such elastic mismatching can lead to increased wave reflections. Therefore, we hypothesize that significantly increased pulse wave reflections associated with a drastically reduced arterial compliance beyond normal aging is a principle contributing factor to the production of ISH. To investigate this, we developed a new allometric hemodynamic model that can account for the arterial compliance and peripheral resistance changes during the progression of aging. This model also affords the time domain analysis of forward and reflected waves during aging and ISH. Results show that a further and much greater reduction in arterial compliance beyond normal aging is necessary to produce ISH. Comparison of ISH with normal aging at 60-year old showed that in ISH the amount of wave reflections is much more pronounced, with a greater amplitude and earlier arrival in systole. The increased wave reflections in ISH further amplify the cyclic stress on the already stiffened blood vessels. Therefore, therapies to treat ISH patients need to focus on reducing pulse wave reflections as well as on improving large vessel compliance.
John K-J Li; Ying Zhu; Dorene O'Hara; Kenneth Khaw
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular engineering (Dordrecht, Netherlands)     Volume:  7     ISSN:  1567-8822     ISO Abbreviation:  Cardiovasc Eng     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132083     Medline TA:  Cardiovasc Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Cardiovascular Engineering Labs, Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd, Piscataway, NJ 08854, USA.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Computer Simulation
Hemodynamics / physiology*
Hypertension / physiopathology*
Middle Aged
Models, Cardiovascular*
Vascular Resistance / physiology

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