| Alloimmunization to red cells in thalassemics: Emerging problem and future strategies. | |
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MedLine Citation:
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PMID: 21856231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS AND OBJECTIVES: To evaluate the magnitude of red cell alloimmunization in regularly transfused patients with thalassemia major and analyse factors responsible for development of antibodies. MATERIALS AND METHODS: This cross sectional study was conducted on 116 thalassemics receiving regular transfusions. All the patients underwent antibody screening. Patients with positive antibody screen were further tested for antibody identification. The data was analysed to find out the frequency, pattern and factors influencing red cell alloimmunization secondary to multiple transfusions. RESULTS: Mean age of the patients was 14years (range 1.5-27years). Red cell alloantibodies were found in 11 patients (9.48%). In four (36%) patients first transfusion was given before 6months of age and in seven (64%) patients, first transfusion was given after two years of age. The interval between consecutive transfusions varied from 18 to 35days. The most common antibody was Anti-E found in 4 (36.4%) patients, followed by Anti-K (three patients, 27.2%), Anti-Kp(a) (two patients, 18.2%) and Anti-C(w) (two patients, 18.2%). The interval from first transfusion to antibody development varied from 1.5 to 14years. None of the eight out of 116 patients, who underwent splenectomy showed any antibody development. CONCLUSIONS: The rate of red cell alloimmunization was found to be 9.48% in thalassemics receiving regular transfusions. The incidence of alloantibody development was higher if first transfusion was received at more than 2years of age. Early institution of red cell transfusions and Rh and Kell phenotyping followed by provision of matched blood could prevent alloimmunization. |
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Authors:
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Richa Gupta; Deepak Kumar Singh; Bharat Singh; Usha Rusia |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-17 |
Journal Detail:
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Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Volume: - ISSN: 1473-0502 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095653 Medline TA: Transfus Apher Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Lab Medicine, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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