Document Detail


Alloimmune thrombocytopenia: in utero treatment by high doses of intravenous gamma globulins.
MedLine Citation:
PMID:  1380248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors report successful in utero treatment by high doses of intravenous gamma globulins in a case of neonatal alloimmune thrombocytopenia. Early diagnosis allows an appropriate management: fetal blood sampling as early as 20 weeks of gestation; in case of fetal thrombocytopenia, treatment by intravenous gamma globulin (1.0 g/kg/b.w.) each week during 8 weeks or more; ultrasound screening of in utero hemorrhage, particularly intracranial hemorrhage; fetal blood sampling before delivery at term and in utero transfusion of platelet antigen negative in case of persistence of fetal thrombocytopenia.
Authors:
P Poulain; C Kaplan; C Leberre; J Milon; C Bergeron; J Y Grall
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  7     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  1992  
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2006-08-26    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  144-6     Citation Subset:  IM    
Affiliation:
Institut National de Transfusion Sanguine, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, Human Platelet
Blood Platelets / immunology
Blood Transfusion, Intrauterine
Female
Fetal Blood / cytology
Fetal Diseases / diagnosis,  therapy*
Humans
Infant, Newborn
Injections, Intravenous
Male
Maternal-Fetal Exchange / immunology
Platelet Count
Platelet Transfusion
Pregnancy
Thrombocytopenia / congenital,  diagnosis,  therapy*
gamma-Globulins / administration & dosage*
Chemical
Reg. No./Substance:
0/1a alloantigen, human; 0/Antigens, Human Platelet; 0/gamma-Globulins

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