| Alloimmune thrombocytopenia: fetal and neonatal losses related to cordocentesis. | |
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MedLine Citation:
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PMID: 7856672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This report describes the increased risks of cordocentesis in fetuses affected with alloimmune thrombocytopenia. STUDY DESIGN: As part of a multicenter treatment study clinical and laboratory data from five pregnancies with alloimmune thrombocytopenia in which there was a fetal or neonatal loss associated with cordocentesis were reviewed. The fetal or neonatal deaths were all thought to be a result of exsanguination. These fetuses were compared with a group of 44 affected fetuses who underwent the same procedure but who survived. The data were analyzed by the Wilcoxon rank-sum test and the two-tailed Fisher's exact test. A p value < 0.05 was considered significant. RESULTS: The mean platelet count at cordocentesis was significantly lower in the cases than in the controls (5.8 vs 32.8 x 10(9)/L, p = 0.005). The incidence of antenatal intracranial hemorrhage in the untreated sibling of the prior affected pregnancy was significantly greater in the cases than in the controls (two of five vs one of 42, p = 0.02). CONCLUSION: Fetuses affected with alloimmune thrombocytopenia are at increased risk for fatal exsanguination associated with cordocentesis. |
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Authors:
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M J Paidas; R L Berkowitz; L Lynch; C J Lockwood; R Lapinski; J G McFarland; J B Bussel |
Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 172 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-15 Completed Date: 1995-03-15 Revised Date: 2006-08-26 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 475-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai Medical Center, New York, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Human Platelet
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immunology Blood Platelets / immunology Case-Control Studies Cordocentesis / adverse effects* Female Fetal Death / etiology* Hemorrhage / etiology*, mortality Humans Infant, Newborn Isoantibodies / blood Platelet Count Pregnancy Risk Factors Thrombocytopenia / diagnosis, immunology, mortality* |
| Chemical | |
Reg. No./Substance:
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0/1a alloantigen, human; 0/Antigens, Human Platelet; 0/Isoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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