Document Detail


Allograft implantation in pediatric cardiac surgery: surgical experience from 1982 to 1994.
MedLine Citation:
PMID:  7646137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between July 1982 and April 1994, a total of 290 patients (median age 6.5 years, range 1 month to 32.1 years, 69 patients younger than 1 year) underwent repair of their cardiac malformation by insertion of an allograft. The diagnoses were truncus arteriosus communis (n = 78, 27.0%), tetralogy of Fallot (n = 59, 20.0%), pulmonary atresia (n = 72, 25.0%), double outlet right ventricle (n = 15, 5.0%), complex transposition of the great arteries plus pulmonary stenosis (n = 37, 13.0%), and others (n = 29, 10.0%). Either pulmonary (n = 69) or aortic (n = 221) cadaver allografts were implanted. Two hundred twenty-nine of the allografts were antibiotic preserved. Since January 1991 (n = 61), a new cryopreservation procedure was employed for standardized uniform cooling using heat sinks and defined package geometry. Follow-up was complete for 95.2% (n = 276, 1,320 patient-years). Thirty-day mortality was 9.0% (n = 26) and late mortality was 12.1% (n = 35). Kaplan-Meier analysis revealed that patient survival was determined mainly by their underlying cardiac disease. All allografts with valve sizes less than 15.0 mm had to be exchanged within 7 years as these patients had outgrown their conduits. When the allograft was larger than 15.0 mm, exchange was necessary in 20% at 10 years. ABO compatibility and aortic or pulmonary origin of the allograft were not significant influences on allograft survival.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J Weipert; H Meisner; N Mendler; J C Haehnel; M Homann; S U Paek; F Sebening
Related Documents :
20093267 - Is advanced age a contraindication for emergent repair of acute type a aortic dissection?
22245747 - Molecular mechanisms of therapeutic hypothermia on neurological function in a swine mod...
19846117 - Cardiovascular abnormalities, interventions, and long-term outcomes in infantile willia...
1417277 - Coarctation of the aorta in infants: does the aortic arch grow after repair?
10202067 - Endoscopic nd:yag laser therapy for villous adenomas of the right colon.
2010437 - A prospective study of aspirin's effect on red blood cell loss in cardiac surgery.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  60     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-20     Completed Date:  1995-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S101-4     Citation Subset:  AIM; IM    
Affiliation:
Department for Cardiovascular Surgery, German Heart Center Munich.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Bacterial Agents
Aortic Valve / transplantation*
Child
Child, Preschool
Cryopreservation
Follow-Up Studies
Graft Survival
Heart Defects, Congenital / mortality,  surgery*
Humans
Infant
Pulmonary Valve / transplantation*
Reoperation
Survival Analysis
Tissue Preservation
Transplantation, Homologous / mortality
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  On the need for improved transfusion indicators in cardiac surgery.
Next Document:  Large-caliber cryopreserved arterial allografts in vascular reconstructive operations: early experie...