Document Detail

Allograft compared with autograft infection rates in primary anterior cruciate ligament reconstruction.
MedLine Citation:
PMID:  20962190     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Injuries to the anterior cruciate ligament are the most common surgically treated knee ligament injury. There is no consensus regarding the optimal graft choice between allograft and autograft tissue. Postoperative septic arthritis is an uncommon complication after anterior cruciate ligament reconstruction. The purpose of this study was to compare infection rates between procedures with use of allograft and autograft tissue in primary anterior cruciate ligament reconstruction. METHODS: A combined prospective and retrospective multicenter cohort study was performed over a three-year period. Graft selection was determined by the individual surgeon. Inclusion and exclusion criteria were equivalent for the two groups (allograft and autograft tissue). Data collected included demographic characteristics, clinical information, and graft details. Patients were followed for a minimum of 5.5 months postoperatively. Our primary outcome was intra-articular infection following anterior cruciate ligament reconstruction. RESULTS: Of the 1298 patients who had anterior cruciate ligament reconstruction during the study period, 861 met the criteria for inclusion and formed the final study group. Two hundred and twenty-one patients (25.6%) received an autograft, and 640 (74.3%) received an allograft. There were no cases of septic arthritis in either group. The 95% confidence interval was 0% to 0.57% for the allograft group and 0% to 1.66% for the autograft group. The rate of superficial infections in the entire study group was 2.32%. We did not identify a significant difference in the rate of superficial infections between autograft and allograft reconstruction in our study group. CONCLUSIONS: While the theoretical risk of disease transmission inherent with allograft tissue cannot be eliminated, we found no increased clinical risk of infection with the use of allograft tissue compared with autologous tissue for primary anterior cruciate ligament reconstruction.
David D Greenberg; Michael Robertson; Santaram Vallurupalli; Richard A White; William C Allen
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  92     ISSN:  1535-1386     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-21     Completed Date:  2010-11-05     Revised Date:  2010-11-16    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2402-8     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, University of Missouri-Columbia, Columbia, Missouri, USA.
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MeSH Terms
Anterior Cruciate Ligament / surgery*
Arthritis, Infectious / epidemiology*
Bone-Patellar Tendon-Bone Graft*
Knee Injuries / surgery*
Middle Aged
Tendons / transplantation*
Tissue and Organ Harvesting
Transplantation, Autologous
Transplantation, Homologous
Young Adult
Comment In:
J Bone Joint Surg Am. 2010 Oct 20;92(14):e22   [PMID:  20962186 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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