| Allograft Pathology in Patients Transplanted for Idiopathic Dilated Cardiomyopathy. | |
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MedLine Citation:
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PMID: 22198008 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: There are few morphologic studies on idiopathic dilated cardiomyopathy (CM) treated with transplant. DESIGN:: We prospectively correlated gross, histologic, and clinical findings pertaining to hearts explanted in a 5-year period from patients with a clinical diagnosis of nonischemic CM and also correlated left ventricular diameter with preoperative echocardiographic reports. RESULTS:: Of 64 patients with a clinical diagnosis of dilated cardiomyopathy (DC), 42 were men (age, 51±13 y) and 22 were women (age, 42±18 y). The pathologic diagnosis was idiopathic (dilated) cardiomyopathy (DC) in 55 patients (86%) and features of specific CM in 9 patients (14%). Specific diagnoses were fibrofatty change consistent with arrhythmogenic right ventricular cardiomyopathy (n=6), amyloidosis (n=2), and sarcoidosis (n=1), none of which were suspected clinically. The 55 hearts with idiopathic DC had a mean heart weight of 508 (range, 220 to 980) g. Pathologic subsets of the DC group included 4 hearts without enlargement, cavity dilatation, or significant histologic findings (minimal DC); 3 hearts with histologic evidence of healed myocarditis; and 5 hearts with mildly noncompacted left ventricle with hypertrabeculation. Five patients had prior mitral or tricuspid valve replacement/repairs to manage heart failure. There were 7 postpartum DC cases, 1 with a histologic pattern of healed myocarditis and 1 alcoholism-associated DC. Familial DC comprised 16% (9 of 55) of patients. In patients without prior assist device placement, pathologic left ventricular cavity diameter correlated with echocardiographic end-diastolic volume (r, 0.8, P<0.0001). CONCLUSION:: Morphologically, DC is a heterogeneous group. Areas of fibrofatty change and features of noncompaction are not uncommon. Left ventricular measurement at explant correlates well with echocardiographic findings, with a relatively consistent underestimation of the diameter. |
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Authors:
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Mingchang Zhang; Fabio Tavora; Thomas Huebner; Jonathan Heath; Allen Burke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
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Title: The American journal of surgical pathology Volume: - ISSN: 1532-0979 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707904 Medline TA: Am J Surg Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*University of Maryland, School of Medicine, Baltimore, MD †Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China ‡Messejana Heart and Lung Hospital, Fortaleza, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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