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Allogeneic stem cell transplantation for chronic myelomonocytic leukemia (CMML): A report from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC).
MedLine Citation:
PMID:  23320648     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES AND METHODS: CMML is a severe disease for which allogeneic stem cell transplantation (allo-SCT) remains the only potentially curative treatment. We describe a retrospective study determining prognostic factors for outcome after allo-SCT in consecutive 73 CMML patients reported to the SFGM-TC registry between 1992 and 2009. RESULTS: At diagnosis, median age was 53 yrs, 36% patients had palpable splenomegaly (SPM). 48/13/9 patients had good/int/poor risk karyotype according to IPSS, 61% patients had CMML1, and 39% CMML-2. 41/31/1 cases had an HLA-identical sibling, an unrelated and haploidentical donor respectively. 43 patients received reduced-intensity conditioning. With a median follow-up of 23 mo, acute grade 2-4 and chronic GVHD developed in 21 and 25 patients respectively. The 3-year OS, NRM (non relapse mortality), EFS and CIR (cumulative incidence of relapse) were 32%, 36%, 29% and 35% respectively. OS was not influenced by the CR status, marrow blasts% at allo-SCT, prior treatments, and cGVHD. Using multivariate analysis, year of transplant<2004 (YOT) (p=0.005) was associated with higher NRM, YOT<2004 (p=0.04) and SPM at allo-SCT (p=0.02) with lower EFS, and YOT<2004 (p=0.03) and SPM at allo-SCT (p=0.04) with poorer OS. CONCLUSIONS: Allo-SCT is a valid treatment option for CMML patients and its outcome has improved with YOT>2004. Splenomegaly seems to be a negative factor of OS and EFS in this series. © 2013 John Wiley & Sons A/S.
Authors:
Sophie Park; Myriam Labopin; Ibrahim Yakoub-Agha; Jacques Delaunay; Nathalie Dhedin; Eric Deconinck; Mauricette Michallet; Marie Robin; Thierry De Revel; Marc Bernard; Norbert Vey; Bruno Lioure; Simona Lapusan; Reza Tabrizi; Jean-Henri Bourhis; Anne Huynh; Yves Beguin; Gérard Socié; François Dreyfus; Pierre Fenaux; Mohamad Mohty
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Hematology, Hôpital Cochin, Université Paris V, Paris, France.
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