Document Detail


Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT).
MedLine Citation:
PMID:  12100129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the results of 50 allogeneic transplantations from related (n = 43) or unrelated (n = 7) donors, performed for chronic myelomonocytic leukaemia (CMML) in 43 European centres. The median age at transplant was 44 years (range 19-61). Eighteen patients had excess blasts ranging from 5% to 30% at the time of transplantation. Two graft failures were observed (4%). Neutrophil (> 0.5 x 109/l) and platelet engraftment (> 50 x 109/l) was reached after a median of 17 d (range 11-38) and 27 d (range 11-48) respectively. Acute graft-versus-host disease (GvHD grade II-IV was seen in 35% of patients, while 20% developed severe-acute GvHD grade III/IV. Twenty-six patients (52%) died of treatment-related causes. After a median follow-up of 40 months (range 11-110), the 5-year-estimated overall survival was 21% (95% CI: 15-27%) and the 5-year-estimated disease-free survival (DFS) was 18% (95% CI: 13-23%). Earlier transplantation in the course of disease, male donor, use of unmanipulated grafts, allogeneic transplantation and occurrence of acute GvHD favoured better DFS, but did not reach statistical significance. The 5-year estimated probability of relapse was 49%. The data showed a trend for a lower relapse probability of acute GvHD grade II-IV (24% vs 54%; P = 0.07), and for a higher relapse rate in patients with T cell-depleted grafts (62% vs 45%), suggesting a 'graft-versus-CMML effect'.
Authors:
Nicolaus Kröger; Tatjana Zabelina; Philipe Guardiola; Volker Runde; Jorge Sierra; Anja Van Biezen; Dietger Niederwieser; Axel R Zander; Theo De Witte
Related Documents :
7920299 - Bone marrow transplantation in taiwan: low incidence of acute gvhd in patients with hem...
17191149 - The effect of natural killer cell killer ig-like receptor alloreactivity on the outcome...
8485479 - Recovery after allogeneic marrow transplantation: prospective study of predictors of lo...
11685119 - Treatment of intestinal graft-versus-host disease using betamethasone enemas.
6764839 - Marrow graft studies in dogs: factors influencing resistance to engraftment and graft-v...
20075159 - Genetic variations in the heparanase gene (hpse) associate with increased risk of gvhd ...
24295869 - Hope for human liver grafts obtained from donors after cardiac death.
12378549 - Management of membranoproliferative glomerulonephritis type ii with plasmapheresis.
9241619 - Still a role for plasma exchange in rapidly progressive glomerulonephritis?
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  British journal of haematology     Volume:  118     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-09-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Affiliation:
University-Hospital Hamburg, Germany. nkroeger@uke.uni-hamburg.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Disease-Free Survival
Female
Follow-Up Studies
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation* / mortality
Humans
Leukemia, Myelomonocytic, Chronic / mortality,  surgery*
Male
Middle Aged
Recurrence
Survival Rate
Transplantation, Homologous
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ethics in sentinel node biopsy in breast cancer: an open question.
Next Document:  Immune reconstitution after haematopoietic cell transplantation in children: immunophenotype analysi...