| Allogeneic serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. | |
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MedLine Citation:
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PMID: 17667623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the use of allogeneic serum eye drops to treat 2 patients with chronic graft-versus-host disease (GVHD)-induced severe ocular surface disease. METHODS: Small case series. RESULTS: Conventional therapy failed to control the ocular symptoms of 2 patients with GVHD who presented with severe dry eye syndrome. Because autologous serum was unavailable in these cases, we used allogeneic serum eye drops as an alternate option for treating their ocular surface disease. Both donors had serologic tests performed before donation. Use of the allogeneic serum eye drops had a beneficial clinical effect, with marked attenuation of the patients' symptoms. This therapy proved to be safe during 10 months of treatment. CONCLUSIONS: Allogeneic serum eye drops may be a good alternative treatment for patients with severe dry eyes caused by GVHD. |
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Authors:
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Chun-Chi Chiang; Jane-Ming Lin; Wen-Lu Chen; Yi-Yu Tsai |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-10-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 861-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow Transplantation Dry Eye Syndromes / drug therapy*, etiology Female Graft vs Host Disease / complications* Hematopoietic Stem Cell Transplantation Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery Male Ophthalmic Solutions / administration & dosage* Serum* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Ophthalmic Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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