Document Detail


Allogeneic islet transplantation.
MedLine Citation:
PMID:  17961088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant progress has been made in the field of beta-cell replacement therapies by islet transplantation in patients with unstable Type 1 diabetes mellitus (T1DM). Recent clinical trials have shown that islet transplantation can reproducibly lead to insulin independence when adequate islet numbers are implanted. Benefits include improvement of glycemic control, prevention of severe hypoglycemia and amelioration of quality of life. Numerous challenges still limit this therapeutic option from becoming the treatment of choice for T1DM. The limitations are primarily associated with the low islet yield of human pancreas isolations and the need for chronic immunosuppressive therapies. Herein the authors present an overview of the historical progress of islet transplantation and outline the recent advances of the field. Cellular therapies offer the potential for a cure for patients with T1DM. The progress in beta-cell replacement treatment by islet transplantation as well as those of emerging immune interventions for the restoration of self tolerance justify great optimism for years to come.
Authors:
Simona Marzorati; Antonello Pileggi; Camillo Ricordi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  7     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-13     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1627-45     Citation Subset:  IM    
Affiliation:
University of Miami Miller School of Medicine, Cell Transplant Center and Clinical Islet Transplant Program, Diabetes Research Institute, 1450 NW, 10th Avenue (R-134), Miami, FL 33136, USA.
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 1 / surgery*
Graft Survival
Humans
Immunosuppression
Insulin / blood,  secretion
Islets of Langerhans Transplantation*
Transplantation, Homologous
Grant Support
ID/Acronym/Agency:
1R01D59993-04//PHS HHS; 1R01DK25802-21/DK/NIDDK NIH HHS; 5R01DK056953/DK/NIDDK NIH HHS; 5R01DK55347/DK/NIDDK NIH HHS; M01RR16587/RR/NCRR NIH HHS; R01DK025802/DK/NIDDK NIH HHS; U42 RR016603/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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