Document Detail

Allogeneic islet transplantation.
MedLine Citation:
PMID:  17961088     Owner:  NLM     Status:  MEDLINE    
Significant progress has been made in the field of beta-cell replacement therapies by islet transplantation in patients with unstable Type 1 diabetes mellitus (T1DM). Recent clinical trials have shown that islet transplantation can reproducibly lead to insulin independence when adequate islet numbers are implanted. Benefits include improvement of glycemic control, prevention of severe hypoglycemia and amelioration of quality of life. Numerous challenges still limit this therapeutic option from becoming the treatment of choice for T1DM. The limitations are primarily associated with the low islet yield of human pancreas isolations and the need for chronic immunosuppressive therapies. Herein the authors present an overview of the historical progress of islet transplantation and outline the recent advances of the field. Cellular therapies offer the potential for a cure for patients with T1DM. The progress in beta-cell replacement treatment by islet transplantation as well as those of emerging immune interventions for the restoration of self tolerance justify great optimism for years to come.
Simona Marzorati; Antonello Pileggi; Camillo Ricordi
Related Documents :
12428738 - Identification of a specific sertoli cell marker, sox9, for use in transplantation.
20097708 - {beta}-cell secretory capacity and demand in recipients of islet, pancreas, and kidney ...
99048 - The fate of intraportally transplanted islets in diabetic rats. a morphologic and immun...
17324008 - Isa 247: trans-isa 247, trans-r 1524, isa(tx)247, isatx 247, isatx247, lx 211, lx211, r...
24773738 - Prognostic value of glomerular filtration rate 1 year after heart transplantation.
9211538 - Febrile complications in the first 100 days after bone marrow transplantation in childr...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  7     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-13     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1627-45     Citation Subset:  IM    
University of Miami Miller School of Medicine, Cell Transplant Center and Clinical Islet Transplant Program, Diabetes Research Institute, 1450 NW, 10th Avenue (R-134), Miami, FL 33136, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetes Mellitus, Type 1 / surgery*
Graft Survival
Insulin / blood,  secretion
Islets of Langerhans Transplantation*
Transplantation, Homologous
Grant Support
1R01D59993-04//PHS HHS; 1R01DK25802-21/DK/NIDDK NIH HHS; 5R01DK056953/DK/NIDDK NIH HHS; 5R01DK55347/DK/NIDDK NIH HHS; M01RR16587/RR/NCRR NIH HHS; R01DK025802/DK/NIDDK NIH HHS; U42 RR016603/RR/NCRR NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stem cell therapy for joint problems using the horse as a clinically relevant animal model.
Next Document:  Electroporation-based DNA immunisation: translation to the clinic.