Document Detail

Allodynia and migraine.
MedLine Citation:
PMID:  22644161     Owner:  NLM     Status:  In-Data-Review    
An impaired processing of sensory afferents in the brainstem plays a key role in the development of migraine attack and for many of its clinical aspects. The repetition or prolonged of painful stimuli over time would be able to produce a prolonged and reversible increase of excitability and synaptic efficacy in the nociceptive pathways of the central nervous system. This phenomenon, known as sensitization, involves specifically the caudal trigeminal nucleus. Being an aspect of untreated migraine, allodynia is more common in patients with chronic migraine and migraine with aura, often associated with motor and sensory symptoms sometimes present during the attacks. The presence of allodynia in the course of migraine attack greatly increases the disability of the patient and its recognition, as well as from a therapeutic point of view, it is essential in the management of migraine patients.
Marco Aguggia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  33 Suppl 1     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  IM    
Neurological Department, C. Massaja Hospital, Via Conte Verde 200 10141, Asti, Italy,
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