Document Detail

Allo-immunization during pregnancy. Clinical results from 1983 to 1989 in a Scandinavian university hospital.
MedLine Citation:
PMID:  1322620     Owner:  NLM     Status:  MEDLINE    
From 1983 to 1989, 147,068 pregnancies were analyzed for allo-immunization against erythrocyte antigens. Approximately half of the cases were due to immunization against factor D and the others were due to allo-immunization against other antigens (K, c, E, etc.). In 61 cases exchange transfusion of the newborn was needed and in 115 cases diagnostic amniocentesis was done during pregnancy. Intrauterine transfusions were performed in 10 cases. Fetal and neonatal mortality was 4% in these moderate to severe cases, all due to immunization against D. Immunization against D was due to failure to give immunoglobulin anti-D in about 2/3 of the cases. Systematic prophylactic treatment with anti-D during pregnancy would probably not be cost-effective in this population.
P Belfrage; P Thomassen; J Floberg; O Akerblom; U Broberger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  71     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-31     Completed Date:  1992-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Blood Transfusion, Intrauterine
Erythroblastosis, Fetal / epidemiology*,  prevention & control,  therapy
Exchange Transfusion, Whole Blood
Infant, Newborn
Peptides / immunology
Rh Isoimmunization / epidemiology*,  therapy
Rh-Hr Blood-Group System / immunology*
Sweden / epidemiology
Reg. No./Substance:
0/Peptides; 0/Rh-Hr Blood-Group System; 0/Rho(D) antigen

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