Document Detail


Alleviative effects of α-lipoic acid supplementation on acute heat stress-induced thermal panting and the level of plasma nonesterified fatty acids in hypothyroid broiler chickens.
MedLine Citation:
PMID:  22404813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The present study was conducted to examine the effects of α-lipoic acid on hypothyroidism-induced negative growth performance and whether α-lipoic acid alleviates acute heat stress in relation to hypothyroid status. 2. Female broiler chickens (14 d-old) were fed diets supplemented with α-lipoic acid (100 mg/kg) and an antithyroid substance, propylthiouracil (200 mg/kg), for 20 d under thermoneutral conditions (25°C). At 42 d of age, chickens were exposed to a high ambient temperature (36°C, 60% RH) for 4 h. 3. Under the thermoneutral condition, propylthiouracil administration decreased feed efficiency and concomitantly increased adipose tissue and thyroid gland weights. Plasma nonesterified fatty acids and triacylglycerol were also increased by propylthiouracil administration. However, α-lipoic acid supplementation did not affect the hypothyroidism-induced effects. 4. In hypothyroid chickens, the rise in respiratory rate induced by heat exposure was greatly inhibited by α-lipoic acid administration at 1 h, but this effect had disappeared at 4 h. In addition, a similar inhibitory effect on the concentrations of plasma nonesterified fatty acids was subsequently observed at 4 h. 5. Therefore, the present study suggested that α-lipoic acid alleviates acute heat stress if chickens are in a hypothyroid status.
Authors:
Y Hamano
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British poultry science     Volume:  53     ISSN:  1466-1799     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-10-09     Revised Date:  2013-06-20    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-33     Citation Subset:  IM    
Affiliation:
Department of Agribusiness, Faculty of Bioresource Sciences, Akita Prefectural University, Ohgata, Akita, Japan. yhamano@akita-pu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animal Feed / analysis
Animals
Body Weight
Chickens
Diet / veterinary
Dietary Supplements
Fatty Acids, Nonesterified / blood
Female
Hot Temperature / adverse effects*
Hypothyroidism / chemically induced,  veterinary*
Poultry Diseases / blood,  chemically induced*
Propylthiouracil / toxicity*
Stress, Physiological / drug effects*
Thioctic Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 51-52-5/Propylthiouracil; 62-46-4/Thioctic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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