Document Detail

Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid.
MedLine Citation:
PMID:  12860277     Owner:  NLM     Status:  MEDLINE    
We showed the inhibitory effect of oleic and palmitoleic acids (OA and POA) on this trans10, cis12 (10t, 12c)-CLA induced cytotoxic activity. When cells were cultured in the presence of 10t, 12c-CLA, this potent cytotoxic effect on dRLh-84 cells was clearly obvious when compared to the control vehicle group. It was revealed that the levels of cellular OA and POA levels decreased upon cis9, trans11 (9c,11t) or 10t, 12c-CLA treatment in a time course dependent manner. OA or POA demonstrates a dose dependent inhibition of the 10t, 12c-CLA induced cytotoxicity. Notable nuclear fragmentation or activation of caspase-3 and 9 by 10t, 12c-CLA in dRLh-84 was counteracted by treatment with OA or POA. Results also suggest that 10t, 12c-CLA induced apoptosis can be inhibited by treatment with OA or POA.
Masao Yamasaki; Hitomi Chujo; Shinsuke Nou; Hirofumi Tachibana; Koji Yamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  196     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2003-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  187-96     Citation Subset:  IM    
R&D division of Omu Milk Products Co. Ltd, 1-38-1 Shin katsudachi Omuta, Fukuoka 836-0895, Japan.
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MeSH Terms
Caspase 3
Caspase 9
Caspases / metabolism
Fatty Acids, Monounsaturated / pharmacology*
Linoleic Acid / pharmacology*
Liver Neoplasms / enzymology,  pathology*
Liver Neoplasms, Experimental / enzymology,  pathology*
Oleic Acid / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:
0/Fatty Acids, Monounsaturated; 112-80-1/Oleic Acid; 2091-29-4/palmitoleic acid; 2197-37-7/Linoleic Acid; EC 3.4.22.-/Casp3 protein, rat; EC 3.4.22.-/Casp9 protein, rat; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases

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