| Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid. | |
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MedLine Citation:
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PMID: 12860277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We showed the inhibitory effect of oleic and palmitoleic acids (OA and POA) on this trans10, cis12 (10t, 12c)-CLA induced cytotoxic activity. When cells were cultured in the presence of 10t, 12c-CLA, this potent cytotoxic effect on dRLh-84 cells was clearly obvious when compared to the control vehicle group. It was revealed that the levels of cellular OA and POA levels decreased upon cis9, trans11 (9c,11t) or 10t, 12c-CLA treatment in a time course dependent manner. OA or POA demonstrates a dose dependent inhibition of the 10t, 12c-CLA induced cytotoxicity. Notable nuclear fragmentation or activation of caspase-3 and 9 by 10t, 12c-CLA in dRLh-84 was counteracted by treatment with OA or POA. Results also suggest that 10t, 12c-CLA induced apoptosis can be inhibited by treatment with OA or POA. |
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Authors:
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Masao Yamasaki; Hitomi Chujo; Shinsuke Nou; Hirofumi Tachibana; Koji Yamada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer letters Volume: 196 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2003-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 187-96 Citation Subset: IM |
Affiliation:
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R&D division of Omu Milk Products Co. Ltd, 1-38-1 Shin katsudachi Omuta, Fukuoka 836-0895, Japan. masawo@agr-kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caspase 3 Caspase 9 Caspases / metabolism Fatty Acids, Monounsaturated / pharmacology* Linoleic Acid / pharmacology* Liver Neoplasms / enzymology, pathology* Liver Neoplasms, Experimental / enzymology, pathology* Oleic Acid / pharmacology* Rats Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Monounsaturated; 112-80-1/Oleic Acid; 2091-29-4/palmitoleic acid; 2197-37-7/Linoleic Acid; EC 3.4.22.-/Casp3 protein, rat; EC 3.4.22.-/Casp9 protein, rat; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
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