| Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. | |
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MedLine Citation:
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PMID: 1906905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cocaine induces vasoconstriction of epicardial coronary arteries in patients with and without coronary artery disease, and this vasoconstriction is particularly marked in segments narrowed by atherosclerosis. To assess the effect of nitroglycerin on cocaine-induced coronary vasoconstriction, computer-assisted quantitative analysis was performed on non-diseased and diseased coronary artery segments in 23 patients (18 men, 5 women, aged 43 to 65 years) 1) at baseline, 2) after administration of intranasal saline solution (in 8 patients) or 2 mg/kg of cocaine (in 15 patients), and then 3) after administration of sublingual placebo (in 6 patients) or 0.4 or 0.8 mg of nitroglycerin (in 9 patients) in the 15 patients given cocaine. In response to cocaine administration, coronary artery cross-sectional area decreased 22 +/- 7% (mean +/- SD) in non-diseased segments (p less than 0.05) and 45 +/- 18% in diseased segments (p less than 0.02). The magnitude of vasoconstriction was greater (p = 0.01) in the diseased segments. Sublingual nitroglycerin abolished the vasoconstriction in both non-diseased and diseased segments. Thus, nitroglycerin alleviates cocaine-induced vasoconstriction in patients with coronary artery disease. |
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Authors:
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W C Brogan; R A Lange; A S Kim; D J Moliterno; L D Hillis |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 18 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-08-26 Completed Date: 1991-08-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 581-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Administration, Sublingual Aged Cocaine / administration & dosage, adverse effects* Coronary Angiography Coronary Artery Disease / physiopathology Coronary Vessels / drug effects* Female Heart Catheterization Humans Male Middle Aged Nitroglycerin / administration & dosage, therapeutic use* Vasoconstriction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-17669/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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